2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-145477
    8(R),11(S)-DiHODE 885215-81-6 98%
    8(R),11(S)-DiHODE is a fungal oxylipin that has been found in Aspergillus.
    8(R),11(S)-DiHODE
  • HY-145506
    1-Stearoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol) sodium 326495-23-2 98%
    1-Stearoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol) (18:0 Lyso PE) sodium is a lysophospholipid containing stearic acid (18:0) at the sn-1 position. It can be used in the generation of micelles, liposomes, and other types of artificial membranes, including lipid-based drug carrier systems.
    1-Stearoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol) sodium
  • HY-145511
    10(S)-HOME 263023-34-3 98%
    10(S)-HOME is an oxylipin.
    10(S)-HOME
  • HY-145518
    C8 Phytoceramide (t18:0/8:0) 249728-93-6 98%
    C8 Phytoceramide (t18:0/8:0) is a ceramide.
    C8 Phytoceramide (t18:0/8:0)
  • HY-145529
    Valeryl-L-carnitine chloride 162040-64-4 98%
    Valeryl-L-carnitine (chloride) is an ester product.
    Valeryl-L-carnitine chloride
  • HY-145530
    (S)-Hydroxychloroquine sulfate 155204-09-4 98%
    (S)-Hydroxychloroquine ((S)-HCQ) sulfate is an isomer of Hydroxychloroquine (HY-W031727). (S)-Hydroxychloroquine sulfate (2.5-20 mg/mL) reduces the rate of insulin degradation in liver homogenates isolated from non-diabetic and diabetic rats. Formulations containing Hydroxychloroquine have been used in the study of malaria, rheumatoid arthritis, and systemic lupus erythematosus.
    (S)-Hydroxychloroquine sulfate
  • HY-145536
    α-D-Glucose-1-phosphate disodium tetrahydrate 150399-99-8 98.0%
    α-D-Glucose-1-phosphate disodium tetrahydrate is used as a starting material for synthesis of glucuronic acid. α-D-Glucose-1-phosphate disodium tetrahydrate can be used as a cytostatic compound essential for cardiopathic therapy, as an antibiotic, as an immunosuppressive agent, and as a circulatory system therapy element.
    α-D-Glucose-1-phosphate disodium tetrahydrate
  • HY-145751
    7α-Hydroxy-DHEA 53-00-9 98%
    7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma.
    7α-Hydroxy-DHEA
  • HY-145782
    Witepsol 91744-42-2 98%
    Witepsol is a selective lipid-based vehicle for use in drug delivery systems.
    Witepsol
  • HY-145978
    3'-OMe-m7GpppGmpG 2089461-54-9 98%
    3'-OMe-m7GpppGmpG is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-OMe-m7GpppGmpG
  • HY-146247
    4'-Fluorouridine triphosphate 1251838-93-3 98%
    4'-Fluorouridine triphosphate (4'-F-UTP) is a monomeric raw material that can be used for nucleic acid synthesis.
    4'-Fluorouridine triphosphate
  • HY-146930
    16:1 SM (d18:1/16:1) 222403-66-9 98%
    16:1 SM (d18:1/16:1) is a phosphosphingolipid.
    16:1 SM (d18:1/16:1)
  • HY-147068
    18:0-20:4 PA sodium 322647-61-0 98%
    18:0-20:4 PA sodium is a phosphatidic acid.
    18:0-20:4 PA sodium
  • HY-147069
    18:2 PA sodium 322647-62-1 98%
    18:2 PA (sodium) is a phosphatidic acid.
    18:2 PA sodium
  • HY-147070
    18:3 PE 34813-40-6 98%
    18:3 PE is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
    18:3 PE
  • HY-147075
    18:3 PG sodium 474943-20-9 98%
    18:3 PG (sodium)is a phosphatidylglycerol.
    18:3 PG sodium
  • HY-14736R
    Azilsartan medoxomil (Standard) 863031-21-4 98%
    Azilsartan medoxomil (Standard) is the analytical standard of Azilsartan medoxomil (HY-14736). This product is intended for research and analytical applications. Azilsartan medoxomil (TAK 491), a prodrug form of Azilsartan (HY-14914), is an orally active angiotensin II receptor type 1 antagonist. Azilsartan medoxomil can be used for the study of essential hypertension.
    Azilsartan medoxomil (Standard)
  • HY-14771S
    Imeglimin-d3 98%
    Imeglimin-d3 (EMD 387008-d3) is deuterium labeled Imeglimin. Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function.
    Imeglimin-d3
  • HY-147760
    Dyrk1A-IN-2 2459657-37-3 98%
    Dyrk1A-IN-2 (Compound 63) is a DYRK1A inhibitor with an EC50 of 37 nM. Dyrk1A-IN-2 exhibits highly potent human β-cell replication-promoting activity and low cytotoxicity.
    Dyrk1A-IN-2
  • HY-14806R
    Teneligliptin (Standard) 760937-92-6 98%
    Teneligliptin (Standard) is the analytical standard of Teneligliptin. This product is intended for research and analytical applications. Teneligliptin (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor. Teneligliptin competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM.
    Teneligliptin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity